Children’s Brain Tumor Tissue Consortium (CBTTC)

The D3b Center’s pioneering research project is the Children’s Brain Tumor Tissue Consortium (CBTTC), a collaborative, multi-institutional research program dedicated to the study and treatment of childhood brain tumors. The D3b team is proud to function as the CBTTC’s Operations Center under the leadership of Executive Chair Angela Waanders, MD, MPH, of Ann & Robert H. Lurie Children’s Hospital of Chicago, and Scientific Chair Adam Resnick, PhD, Co-director of the D3b Center at Children’s Hospital of Philadelphia.

The CBTTC supports the research of new prognostic biomarkers and therapies for children with pediatric brain tumors. This collaborative research effort consists of 17 primary member institutions and has enrolled more than 3,300 subjects and collected more 40,000 tubes of specimens since its formation. These specimen collections are all highly annotated and are paired with longitudinal clinical data, genomic data, imaging data and histology data and are available for request by researchers across the world.

In September of 2018, the CBTTC launched the Pediatric Brain Tumor Atlas (PBTA), one of the world’s largest pediatric brain tumor data sets available without embargo. Users can search PBTA files and associated meta data through the Gabriella Miller Kids First Data Resource Portal. Additionally, users can identify genomic and other types of files, then integrate them into a Cavatica workspace for further research of the raw genomic data. A summary of PBTA data and data visualizations are also available on PedcBioPortal.

Researchers can request access to the raw genomic data by completing and submitted the CBTTC Data Access Request form.


Download the CBTTC Data Access Agreement


CBTTC Member Institutions

Biospecimen samples including tissue, blood, cerebral spinal fluid, and other types are carefully stored at the CBTTC’s operations center located at Children’s Hospital of Philadelphia

Children’s Hospital of Philadelphia (Operations Center)

Seattle Children’s Hospital

UPMC Children’s Hospital of Pittsburgh

Ann & Robert H. Lurie Children’s Hospital of Chicago

UCSF Benioff Children’s Hospital

Lucile Packard Children’s Hospital Stanford

Meyer Children’s Hospital (Florence, Italy)

Weill Cornell Medicine Pediatric Brain and Spine Center

Children’s National Health System

Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center

University of California Santa Cruz – Treehouse Childhood Cancer Initiative

The Beijing Tiantan Hospital Neurosurgery Center (Beijing, China)

Genebank/Beijing Genomics Institute (Shenzhen, China)

Dayton Children’s Hospital

The Hudson Institute of Medical Research (Melbourne, Australia)

Wake Forest Baptist Health – Brenner Children’s Hospital


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