Payal Jain, PhD


Center for Data Driven Discovery in Biomedicine

Payal Jain is a senior research scientist leading key translational research projects that focus on developing targeted therapeutics for pediatric solid tumors (CNS and non-CNS). Dr. Jain’s research integrates genomic discoveries, cancer biology and clinical application to drive novel biomarker and therapeutics discovery. Several of her research projects focus on improved understanding of gene fusion biology in pediatric solid tumors and translating these findings to develop potent and safe precision medicine approaches to improve treatment standards in oncology. For this, her team utilizes relevant in vitro assays, cellular model systems and in vivo mouse preclinical models.

Dr. Jain is also a part of the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and Children’s Brain Tumor Network (CBTN) and leads a cutting-edge bioinformatic project in pediatric brain tumors that analyzes multi-omics data from precision medicine clinical trials. The goal is to build a standard research workflow to streamline our research efforts into a high-throughput process utilizing large-scale sequencing data generated by D³b. To share her findings with the community at-large, Dr. Jain actively participates in writing scientific manuscripts, giving presentations, and talking to patient families and funding partners.

Dr. Jain has been driving successful research projects since joining CHOP in August of 2016. She earned a B.Tech in Biotechnology from Amity University in India before completing a MA in Biotechnology from Columbia University in New York, NY. Dr. Jain completed a PhD in Biomedical Sciences at the University of Pennsylvania. She is the recipient of several awards including the prestigious St. Baldrick’s Research Grant.