Chao Zhao, MS


Center for Data Driven Discovery in Biomedicine

Chao Zhao is a Biostatistician responsible for conducting statistical analyses on clinical research in R/SAS statistical computing environments and providing innovative insights to improve healthcare processes and outcomes. He performs parametric/nonparametric tests by applying different regression models to their corresponding cross-sectional or longitudinal clinical cohorts. Chao ensures the appropriate clinical studies are enhanced with statistical power for grant applications, along with the proposal of statistical analysis plans (SAP) in accordance with statistical methods.

Chao’s research focuses on the effect of brain tissue oxygen monitoring in pediatric patients with severe traumatic brain injury (TBI), which causes substantial disability and morbidity. Despite indications in the adult TBI population that direct brain tissue oxygen monitoring may improve long-term clinical outcomes,  the corresponding research in the pediatric population is lacking. Additionally, Chao’s research interests focus on the Pediatric Brain Tumor Atlas (PBTA), investigating the effect of genes RNA expression levels in the different tumors on the patients’ survival probability.

Prior to joining the D3b Center in August of 2021, Chao worked as a biostatistician in the Multiple Sclerosis Healthcare Center at University of California, San Francisco. There he provided advanced statistical supports for MS EPIC cohorts which enrolled more than 700 MS patients since 2004. Chao also made important contributions to discover the “silent progression” in relapse-remitting patients, which greatly changed the MS field.

Chao has contributed to several product development projects with pharmaceutical companies such as new biomarker neurofilament with Novartis, new drug MD1003c with MedDay Pharmaceutical SA, among others. Chao has statistically supported clinical research efforts for more than 20 academic papers, publishing in notable journals including the Journal of the American Medical Association (JAMA) Neurology and Annals of Neurology.

Chao completed MS degrees in both Biology and Statistics from Georgia State University. He is committed to conducting advanced statistical analyses on large complex clinical datasets to interpret the numeric facts in the D3b center at CHOP. Chao is devoted to using data to tell the stories of pediatric patients at CHOP and ultimately advancing children’s health across the globe.