The Center for Data Driven Discovery in Biomedicine (D³b)

Welcome to The Center for Data-Driven Discovery in Biomedicine

Breakthroughs for every child, every time, everywhere

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Learn more about the research initiatives and breakthroughs happening every day throughout The Center for Data Driven Discovery in Biomedicine.  The center brings together leading clinical care professionals, data scientists, bioinformaticians and other researchers to discover cures and better therapeutics for children diagnosed with cancer and other diseases.

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    The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

    Abstract PURPOSE: Clinicians and researchers must contextualize a patient’s genetic variants against population-based references with detailed phenotyping. We sought to establish globally scalable technology, policy, and procedures for…

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    Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models

    Abstract Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. PARP-1 is…

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    Pediatric spinal cord biopsy: A case series from a high-volume referral center

    Abstract Pediatric patients presenting with intramedullary spinal cord lesions often require specific diagnoses to guide their treatment plans. Though results from magnetic resonance imaging and lumbar puncture may…

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    Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma

    Abstract Neuroblastoma is a cancer of the developing sympathetic nervous system. It is diagnosed in 600-700 children per year in the United States and accounts for 12% of…

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    A pilot precision medicine trial for children with diffuse intrinsic pontine glioma—PNOC 003: A report from the Pacific Pediatric Neuro‐Oncology Consortium

    Abstract This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing (RNAseq) of paired normal and tumor tissues could be incorporated into a personalized treatment plan…

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    Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers

    Abstract Gene fusions are one of the most common genomic alterations in pediatric cancer. Many fusions encode oncogenic drivers and play important roles in cancer diagnosis, risk stratification,…