PedcBioPortalPedCBioPortal is an online, cloud-based cancer visualization and analytics application to empower analysis of pediatric cancer data

PedcBioPortal is a cloud-based application that allows researchers to search, analyze and visualize pediatric genomic data to discover cures and more effective therapies for pediatric cancers.  PedcBioPortal was developed to address the lack of pediatric cancer data available in genomic databases such as TARGET. Modeled after the adult cancer database cBioPortal, PedcBioPortal integrates published pediatric cancer data with data collected from consortia-based research. The portal provides access to genomic data provided by The Children’s Brain Tumor Tissue Consortium (CBTTC), the Pediatric NeuroOncology Consortium (PNOC), and the SU2C St. Baldrick’s Pediatric Cancer Dream Team.

PedcBioPortal allows researchers to more easily access large sets of genomic data and enables them to view raw data files and biospecimen samples. This expanded access allows users to quickly locate relevant data for their research and discovery efforts, such as mutations and copy number aberrations along the genome, correlations between gene expression profiles, and protein-protein interaction networks. Additionally, clinical trials data, pharmacological agent information, pathology reports, and tissue images are all incorporated, demonstrating the platform’s ability to store both structured and unstructured data.

Researchers can view and interact with this data in real-time within the portal, or download for additional investigation as part of external research projects.  Application programming interfaces (API) allow bioinformaticians and data scientists to analyze large sets of data within PedcBioPortal.

PedcBioportal software is developed and maintained by a multi-institutional team, consisting of Memorial Sloan-Kettering Cancer Center, Dana Farber Cancer Institute, Princess Margaret Cancer Centre in Toronto, Children’s Hospital of Philadelphia, The Hyve in the Netherlands, and Bilkent University in Ankara, Turkey.

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