PedcBioPortalPedCBioPortal is an online, cloud-based cancer visualization and analytics application to empower analysis of pediatric cancer data

PedcBioPortal is an NIH-funded childhood cancer visualization tool modeled upon and partnered with the highly successful, adultfocused, cBioPortal, which was originally developed at Memorial Sloan-Kettering Cancer Center (MSK). PedcBioPortal provides access to high-level processed data types and supports the curation and cross-cancer integration of public, childhood cancer genomic information.

These ‘open science’ initiatives of consortia-based efforts include the Children’s Brain Tumor Network (CBTN), the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and the St. Baldrick Pediatric Stand Up 2 Cancer Dream Team with the AACR Project Genie as an upcoming integration.

Since the beginning of FY18, an additional number of pediatric and adult cancer sets have been made available through PedcBioPortal, in conjunction with publications. The launch of the Pediatric Brain Tumor Atlas (PBTA) also prompted the release of somatic mutation data, copy number variations, and gene expression levels. This platform allows straight-forward visualization and analysis of the processed data, including the ability to view mutations and copy number aberrations along the genome, identifying correlations between gene expression profiles, and interacting with protein-protein networks.

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