Publications

Date Title Author Journal
10/18/2017 Comprehensive Analysis of Hypermutation in Human Cancer Campbell, BB., Light, N., Fabrizio, D., Zatzman, M., Fuligni, F., de Borja, R., Davidson, S., Edwards, M., Elvin, JA., Hodel, KP., Zahurancik, WJ., Suo, Z., Lipman, T., Wimmer, K., Kratz, CP., Bowers, DC., Laetsch, TW., Dunn, GP., Johanns, TM., Grimmer, MR., Smirnov, IV., Larouche, V., Samuel, D., Bronsema, A., Osborn, M., Stearns, D., Raman, P., Cole, K., Storm, PB., Yalon, M., Opocher, E., Mason, G., Thomas, GA., Sabel, M., George, B., Ziegler, DS., Lindhorst, S., Issai VM., Constantini, S., Toledano, H., Elhasid, R., Farah, R., Dvir, R., Dirks, P., Huang, A., Galati, MA., Chung, J., Ramaswamy, V., Irwin, MS., Aronson, M., Durno, C., Taylor, MD., Rechavi, G., Maris, JM., Bouffet, E., Hawkins, C., Costello, JF., Meyn, MS., Pursell, ZF., Malkin, D., Tabori, U., Shlien, A. PubMed Details
10/9/2017 Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma Alan Mackay, Anna Burford, Diana Carvalho, Elisa Izquierdo, Janat Fazal-Salom, Kathryn R. Taylor, Lynn Bjerke, Matthew Clarke, Mara Vinci, Meera Nandhabalan, Sara Temelso, Sergey Popov, Valeria Molinari, Pichai Raman, Angela J. Waanders, Harry J. Han, Saumya Gupta, Lynley Marshall, Stergios Zacharoulis, Sucheta Vaidya, Henry C. Mandeville, Leslie R. Bridges, Andrew J. Martin, Safa Al-Sarraj, Christopher Chandler, Ho-Keung Ng, Xingang Li, Kun Mu, Saoussen Trabelsi, Dorra H’mida-Ben Brahim, Alexei N. Kisljakov, Dmitry M. Konovalov, Andrew S. Moore, Angel Montero Carcaboso, Mariona Sunol, Carmen de Torres, Ofelia Cruz, Jaume Mora, Ludmila I. Shats, João N. Stavale, Lucas T. Bidinotto, Rui M. Reis, Natacha Entz-Werle, Michael Farrell, Jane Cryan, Darach Crimmins, John Caird, Jane Pears, Michelle Monje, Marie-Anne Debily, David Castel, Jacques Grill, Cynthia Hawkins, Hamid Nikbakht, Nada Jabado, Suzanne J. Baker, Stefan M. Pfister, David T.W. Jones, Maryam Fouladi, André O. von Bueren, Michael Baudis, Adam Resnick, Chris Jones Cancer Cell Details
9/15/2017 Overcoming Resistance to Single-agent Therapy for Oncogenic BRAF Gene Fusions via Combinatorial Targeting of MAPK and PI3K/mTOR Signaling Pathways Payal Jain, Amanda Silva, Harry J. Han, Shih-Shan Lang, Yuankun Zhu, Katie Boucher, Tiffany E. Smith, Aesha Vakil, Patrick Diviney, Namrata Choudhari, Pichai Raman, Christine M. Busch, Tim Delaney, Xiaodong Yang, Aleksandra K. Olow, Sabine Mueller, Daphne Haas-Kogan, Elizabeth Fox, Phillip B. Storm, Adam C. Resnick and Angela J. Waanders Oncotarget Details
9/11/2017 Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma Kristopher R. Bosse, Pichai Raman, Zhongyu Zhu, Maria Lane, Daniel Martinez, Sabine Heitzeneder, Komal S. Rathi, Nathan M. Kendsersky, Michael Randall, Laura Donovan, Sorana Morrissy, Robyn T. Sussman13, Doncho V. Zhelev, Yang Feng, Yanping Wang, Jennifer Hwang, Gonzalo Lopez, Jo Lynne Harenza, Jun S. Wei, Bruce Pawel, Tricia Bhatti, Mariarita Santi, Arupa Ganguly, Javed Khan, Marco A. Marra, Michael D. Taylor, Dimiter S. Dimitrov, Crystal L. Mackall, John M. Maris Cancer Cell Details
8/14/2017 CRAF Gene Fusions in Pediatric Low-grade Gliomas Define a Distinct Drug Response Based on Dimerization Profiles Jain, P., T. M. Fierst, H. J. Han, T. E. Smith, A. Vakil, P. J. Storm, A. C. Resnick, and A. J. Waanders. Oncogene Details
8/2/2017 Shared ACVR1 Mutations in FOP and DIPG: Opportunities and Challenges in Extending Biological and Clinical Implications Across Rare Diseases Harry J. Han , Payal Jain, Adam C. Resnick, Children's Hospital of Philadelphia Bone Details
5/31/2017 Pediatric Low-grade Gliomas with CRAF Gene Fusions are Therapeutically Distinct from Braf-Fusions Based on Dimerization Mediated by N-Terminal Fusion Partner Payal Jain Tamara M. Fierst Harry Han Tiffany Smith Phillip J. Storm Angela J. Waanders Adam C. Resnick Neuro Oncology Details
4/4/2017 The Pediatric Brain Tumor Atlas: Building an Integrated, Multi-platform Data-Rich Ecosystem For Collaborative Discovery in the Cloud Adam C. Resnick, Phillip B. Storm, Angela J. Waanders, Jena V. Lilly, Rishi R. Lulla, Sabine Mueller, Michael Prados, Leonard S. Sender, Allison Heath, Alex S. Felmeister, Anthony Cros, Yuankun Zhu, Pichai Raman, Children's Hospital of Philadelphia, UCSF Benioff Children's Hospital, CHOC Children's, Ann & Robert H. Lurie Children's Hospital of Chicago American Association of Cancer Research (AACR) Details
2/20/2017 Transcriptome Analysis of IL-10-stimulated (M2c) Macrophages by Next-generation Sequencing Lurier, E.B., Dalton, D., Dampier, W., Raman, P., Nassiri, S., Ferraro, N.M., Rajagopalan, R., Sarmady, M. and Spiller, K.L. Immunobiology Details
12/20/2016 Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome Olivia M. Padovan-Merhar , Pichai Raman , Irina Ostrovnaya, Karthik Kalletla, Kaitlyn R. Rubnitz, Eric M. Sanford, Siraj M. Ali, Vincent A. Miller, Yael P. Mossé, Meaghan P. Granger, Brian Weiss, John M. Maris , Shakeel Modak PLOS Genetics Details
12/14/2016 MYB-QKI Drives Childhood Brain Tumors via Tripartite Mechanism Payal Jain & Adam C. Resnick, Center for Data Driven Discovery in Biomedicine at Children's Hospital of Philadelphia Cell Cycle Details
11/21/2016 PedcBioPortal: A cancer data visualization tool for integrative pediatric cancer analyses Pichai Raman, Alex S Felmeister, Phillip B Storm, Rishi R.Lulla, Angela J Waanders, and Adam C Resnick, on behalf of the complete team membership of the Children’s Brain Tumor Tissue Consortium (CBTTC)., CBTTC THE SOCIETY FOR NEURO-ONCOLOGY Details
11/7/2016 PedcBioPortal: A Cancer Data Visualization Tool for Integrative Pediatric Cancer Analyses Pichai Raman, Adam C Resnick, Phillip B Storm, Sabine Mueller, Nikolaus Schultz, Ethan Cerami, John M Maris, Angela J Waanders. Neuro-Oncology Details
11/1/2016 Inositol Polyphosphates Intersect with Signaling and Metabolic Networks via Two Distinct Mechanisms Wu M, Chong LS, Perlman DH, Resnick AC, Fiedler D Proceedings of the National Academy of Sciences of the United States of America Details
10/31/2016 Cavatica: empowering research with a pediatric genomic cloud Pichai Raman, Alex S Felmeister, Phillip B Storm, Rishi R.Lulla, Angela J Waanders, and Adam C Resnick, on behalf of the complete team membership of the Children’s Brain Tumor Tissue Consortium (CBTTC)., CBTTC CAC2 Details
8/18/2016 The Biorepository Portal Toolkit: An Honest-Brokered, Modular, Service-Oriented Software Tool Set for Biospecimen-driven Translational Research Alex S. Felmeister, Aaron J. Masino, Tyler J. Rivera, Adam C. Resnick and Jeffrey W. Pennington, Children's Hospital of Philadelphia BioMed Central Genomics Details
7/1/2016 Pediatric Low-grade Gliomas with CRAF Fusions Respond Differentially to Targeted Therapeutics Based on their Dimerization Profiles Payal Jain, Tamara Fierst, Amanda Silva, Jake Budlow, Harry Han, Phillip B. Storm, Angela Waanders and Adam Resnick AACR Cancer Research Details
7/1/2016 Pediatric low-grade gliomas with CRAF fusions respond differentially to targeted therapeutics based on their dimerization profiles Payal Jain, Tamara Fierst, Amanda Silva, Jake Budlow, Harry Han, Phillip B. Storm, Angela Waanders, and Adam Resnick American Association for Cancer Research Details
6/18/2016 Development of robust in vitro and in vivo preclinical models for diffuse intrinsic pontine glioma Yadavilli S, Yang X, Kilburn L, Kilburn L, Magge S, Kambhampati M, Waanders A, Han H. Muellar S, Resnick A, Packer R, Nazarian J Neuro-Oncology Details
5/30/2016 ACVR1-Mutant diffuse intrinsic pontine gliomas (DIPGS) acquire abeerant activin-mediated bmp pathway activation Harry Han, Valerie Baubet, Katie Boucher, Robert Pignolo, Frederick Kaplan, Eileen Shore, Phillip Storm, Nadia Dahmane, and Adam Resnick Neuro-Oncology Details
5/30/2016 Precision Medicine Approach for Children with Diffuse Intrinsic Pontine Glioma Mueller S, Liang W, Gupta N, Kuhn J, Kilburn L, Crawford J, Banerjee A, Nazemi K, Packer R, Nazarian J, Petritsch C, Truffaux N, Roos A, Nicolaides T, Waanders A, Resnick A, Craig D, Carpten J, Byron S, Berens M, Prados M Neuro-Oncology Details
2/1/2016 MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism Pratiti Bandopadhayay, Lori A Ramkissoon, Payal Jain, Guillaume Bergthold, Jeremiah Wala, Rhamy Zeid, Steven E Schumacher, Laura Urbanski, Ryan O'Rourke, William J Gibson, Kristine Pelton, Shakti H Ramkissoon, Harry J Han, Yuankun Zhu, Namrata Choudhari, Amanda Silva, Katie Boucher, Rosemary E Henn, Yun Jee Kang, David Knoff, Brenton R Paolella, Adrianne Gladden-Young, Pascale Varlet, Melanie Pages, Peleg M Horowitz, Alexander Federation, Hayley Malkin, Adam A Tracy, Sara Seepo, Matthew Ducar, Paul Van Hummelen, Mariarita Santi, Anna Maria Buccoliero, Mirko Scagnet, Daniel C Bowers, Caterina Giannini, Stephanie Puget, Cynthia Hawkins, Uri Tabori, Almos Klekner, Laszlo Bognar, Peter C Burger, Charles Eberhart, Fausto J Rodriguez, D Ashley Hill, Sabine Mueller, Daphne A Haas-Kogan, Joanna J Phillips, Sandro Santagata, Charles D Stiles, James E Bradner, Nada Jabado, Alon Goren, Jacques Grill, Azra H Ligon, Liliana Goumnerova, Angela J Waanders, Phillip B Storm, Mark W Kieran, Keith L Ligon, Rameen Beroukhim, Adam C Resnick Nature Genetics Details
1/30/2016 A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 Protein selectively cleaves the β- Phosphate from 5-Diphosphoinositol pentakisphosphate (5PP-IP5) Elizabeth A. Steidle, Lucy S. Chong, Mingxuan Wu, Elliot Crooke, Dorothea Fiedler, Adam C. Resnick and Ronda J. Rolfes Journal of Biological Chemistry Details
12/17/2015 Scalable Biobanking: A Modular Electronic Honest Broker and Biorepository for Integrated Clinical, Specimen and Genomic Research Alex S. Felmeister, Tyler J. Rivera, Aaron J. Masino, Adam C. Resnick, Jeffrey W. Pennington, Children's Hospital of Philadelphia 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Details
4/21/2015 Combinatorial pathway targeting approaches for BRAF fusions associated with pediatric low-grade gliomas. Waanders A, Silva A, Chen S-S, Han H, Zhu Y, Boucher K, Jain P, Fierst T, Choudhari N, Mueller S, Haas-Kogan D, Storm P, Resnick A Neuro Oncology Details
4/21/2015 Targeted combinatorial approach for treatment of pediatric low grade gliomas in the context of BRAFV600E and KIAA1549:BRAF mutations. Olow AK, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick A, Waanders A, Berger M, Gupta N, James CD, Hass-Kogan D Neuro Oncology Details
4/21/2015 Effects of TORC1/2 inhibitor MLN0128 alone and in combination with MEK inhibition in BRAF mutated glioma cells. Mueller S, Dik R, Yang X, Aleksandra O, Gustafson C, DuBois S, Weiss W, Waanders A, Resnick A, Haas-Kogan D Neuro-Oncology Details
2/3/2014 Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, ThornerAR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER Jr, Stewart C, LigonKL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S. Nature Genetics Details