Transcriptome signatures associated with meningioma progression
Abstract Meningiomas are the most common primary brain tumor of adults. The majority are benign (WHO grade I), with a mostly indolent course; 20% of them (WHO grade…
Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Network (CBTN) and Pediatric Brain Tumor Atlas (PBTA)
ABSTRACT Background Pediatric high grade glioma (pHGG) remains a fatal disease. Increased access to richly annotated biospecimens and patient derived tumor models will accelerate pHGG research and support translation…
Genomics Driven Feasibility Trial to Guide a Precision Medicine Approach for Children with Diffuse Intrinsic Pontine Glioma: A Report from the Pacific Pediatric Neuro-Oncology Consortium (PNOC)
Abstract This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing (RNAseq) of paired normal and tumor tissues could be incorporated into a personalized treatment plan…
Systemic BCNU Enhances the Efficacy of Local Delivery of a Topoisomerase I Inhibitor Against Malignant Glioma
Abstract PURPOSE: To investigate the ability of systemically delivered BCNU to enhance the activity of either systemically delivered irinotecan (CPT-11) or locally delivered camptothecin from a biodegradable polymer…
Surgical Clipping Of A PICA Aneurysm In A 6-Month Old Child
Cervical Chordoma in a Patient with Tuberous Sclerosis Presenting with Shoulder Pain
Endovascular and Surgical Treatment of Ruptured Cerebral Aneurysms in Pediatric Patients
Abstract OBJECTIVE: Pediatric cerebral aneurysms are rare. There are very few recent studies that focus on the multidisciplinary treatment of ruptured aneurysms. We reviewed our pediatric endovascular and…
Treatment of a Malignant Peripheral Nerve Sheath Tumor and its Complications Through a Multidisciplinary Approach
Abstract The authors report the case of a 14-year-old girl with a residual malignant peripheral nerve sheath tumor after thoracotomy, chemotherapy, and radiation therapy. The residual tumor, which…
Interictal EEG Spikes Identify The Region of Electrographic Seizure Onset in Some, But Not All, Pediatric Epilepsy Patients
Abstract Purpose The role of sharps and spikes, interictal epileptiform discharges (IEDs), in guiding epilepsy surgery in children remains controversial, particularly with intracranial EEG (IEEG). While ictal recording…
Spinal Cord Ependymomas and Myxopapillary Ependymomas on the First 2 Decades of Life: A Clinicopathological and Immunohistochemical Characterization of 19 Cases
Abstract OBJECT: Primary spinal cord ependymomas (EPNs) are rare in children, comprising classical WHO Grade II and III tumors and Grade I myxopapillary ependymomas (MEPNs). Despite their benign…