Joseph Dybas, PhD

Proteomics Lead & Bioinformatics Scientist

Center for Data Driven Discovery in Biomedicine

Joseph Dybas is the Proteomics Lead and Bioinformatics Scientist responsible for developing and implementing strategies and methods to leverage proteomics data to characterize and understand the molecular basis of childhood cancers. Joseph integrates proteomics data with other NGS data modalities to develop proteogenomics analyses of primary tumor samples. Additionally, he interprets and assimilates proteomics and other genomics data to elucidate relevant biology and identify molecular mechanisms, biomarkers, and therapeutic and translational targets of pediatric cancers.

Joseph joined the D3b Center in July of 2023. For his PhD thesis research, he developed a computational method to analyze protein structures and identify evolutionary relationships between proteins that exhibit disparate sequence and structure characteristics.
During his Postdoc, in the lab of Dr. Matt Weitzman at CHOP, Joseph implemented proteomics approaches to study cellular immunity and host-pathogen interactions. He developed a research program using integrated proteomics techniques to study host and viral proteome remodeling during viral infection, with a specific focus on elucidating how viral-mediated post-translational modifications target host proteins and impact cellular processes.

Joseph earned BS and MS degrees in Biomedical Engineering from Boston University, before completing a PhD in Biomedical Sciences from the Department of Systems and Computational Biology from Albert Einstein College of Medicine. He is committed to integrating proteomics data with the already strong clinical and genomics data within the multi-disciplinary environment of D3b, to thereby drive novel and innovative translational research. Joseph is inspired by the passionate, collaborative, and open scientific approach within D3b, which provides exciting opportunities toward transformative discoveries to address pediatric cancers.