Supervisory Bioinformatics Scientist
Center for Data Driven Discovery in Biomedicine
Jo Lynne Rokita is a Supervisory Bioinformatics Scientist responsible for leading collaborative, interdisciplinary scientific research projects that bridge the preclinical and DAME units. She supervises members of the data analytics team and performs large-scale genomics research. Jo Lynne’s broad research interests lie in identifying and validating novel coding, noncoding, epigenetic, and/or transcriptional mechanisms contributing to oncogenesis, tumor evolution, and progression/relapse of pediatric high-grade diffuse astrocytic tumors. She combines molecular, genomics, and machine learning approaches to discover and validate novel actionable oncogenic targets and/or pathways with the overall goal of informing current therapeutic regimens leading to future clinical trials.
Jo Lynne joined CHOP in 2015 and prior to joining D3b, she led integrative genomics research in the Maris Laboratory focused on genomic characterization of pediatric PDX models, defining the sub-clonal landscape of high-risk neuroblastoma, and elucidating epigenomic mechanisms of transcriptional repression in MYCN-amplified neuroblastoma. Prior to joining CHOP, Jo Lynne led the development efforts for clinical genetics reference materials at the National Institute of Standards and Technology.
Jo Lynne received her B.S. from the Pennsylvania State University, M.S. from Arcadia University, and earned her Ph.D. in pharmacology and toxicology from Virginia Commonwealth University. She is passionate about, and committed to, using genomics to improve survival and quality of life for children with malignant brain tumors.