De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus
Abstract Congenital hydrocephalus (CH), featuring markedly enlarged brain ventricles, is thought to arise from failed cerebrospinal fluid (CSF) homeostasis and is treated with lifelong surgical CSF shunting with substantial…
Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response
Abstract T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the side effects…
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
Abstract In the present study, DNA from 27 grade I and grade II pediatric gliomas, including ganglioglioma, desmoplastic infantile ganglioglioma, dysembryoplastic neuroepithelial tumor, and pleomorphic xanthoastrocytoma was analyzed…
Use Of Allogeneic Skin Graft For The Closure Of Large Meningomyeloceles: Technical Case Report
Abstract OBJECTIVE AND IMPORTANCE: To describe an alternative approach to the operative management of large meningomyeloceles, in which primary closure is not possible. CLINICAL PRESENTATION: Two full-term infants…
Cranial irradiation increases risk of stroke in pediatric brain tumor survivors
Abstract BACKGROUND AND PURPOSE: The purposes of this study were to determine the incidence of neurovascular events as late complications in pediatric patients with brain tumor and to…
Comparison Of Novel Computer Detectors And Human Performance For Spike Detection In Intracranial EEG
Abstract Objective Interictal spikes in intracranial EEG (iEEG) may correlate with epileptogenic cortex, but review of interictal iEEG is labor intensive. Accurate automated spike detectors are necessary for understanding the…
Predictors Of Outcome In Childhood Intracerebral Hemorrhage: A Prospective Consecutive Cohort Study
Abstract BACKGROUND AND PURPOSE: The purposes of this study were to describe features of children with intracerebral hemorrhage (ICH) and to determine predictors of short-term outcome in a…
ABC/XYZ Estimates Intracerebral Hemorrhage Volume As A Percent Of Total Brain Volume In Children
Abstract BACKGROUND AND PURPOSE: Intracerebral hemorrhage volume (ICHV) as a percentage of total brain volume (TBV) is a strong predictor of outcome in childhood intracerebral hemorrhage with ICHV/TBV…