Adding Value to Liquid Biopsy for Brain Tumors: The Role of Imaging
Clinical management in neuro-oncology has shifted to an integrated method that combines molecular profiles with histopathological and imaging data. Liquid biopsy is a non-invasive method that captures the…
Radio-pathomic Approaches in Pediatric Neuro-Oncology; Opportunities and Challenges
With medical software platforms moving to cloud environments with scalable storage and computing, the translation of predictive artificial intelligence (AI) models to aid in clinical decision-making and facilitate…
Statistical Plots in Oncologic Imaging, A Primer for Neuroradiologists
The simplest approach to convey the results of scientific analysis, which can include complex comparisons, is typically through the use of visual items, including figures and plots. These…
Radiomics for Characterization of the Glioma Immune Microenvironment
Increasing evidence suggests that besides mutational and molecular alterations, the immune component of the tumor microenvironment also substantially impacts tumor behavior and complicates treatment response, particularly to immunotherapies….
Current State of Pediatric Neuro-oncology Imaging, Challenges and Future Directions
Imaging plays a central role in neuro-oncology including primary diagnosis, treatment planning, and surveillance of tumors. The emergence of quantitative imaging and radiomics provided an uprecedented opportunity to…
Unsupervised Machine Learning Using K-means Identifies Radiomic Subgroups of Pediatric Low-grade Gliomas that Correlate with Key Molecular Markers
Despite advancements in molecular and histopathologic characterization of pediatric low-grade gliomas (pLGGs), there remains significant phenotypic heterogeneity among tumors with similar categorizations. We hypothesized that an unsupervised machine…
Radiomics and Radiogenomics in Pediatric Neuro-oncology: A Review
The current era of advanced computing has allowed for the development and implementation of the field of radiomics. In pediatric neuro-oncology, radiomics has been applied in determination of…
First-of-its-Kind Open-Analysis Platform for Pediatric Brain Tumors Provides Robust Data Resource for Childhood Cancer Research
– Collaboration among CHOP, Alex’s Lemonade Stand Foundation, the Pacific Pediatric Neuro-Oncology Consortium, and Children’s Brain Tumor Network paves the way for new collaborative models to accelerate discoveries…
Indigenous Inclusion in Sample-based Research
Not only should cultural literacy and respect be prioritized in our daily lives, but both tenets are necessary for quality medical research. The Children’s Brain Tumor Network…
Researchers Uncover New Understanding of Medulloblastoma in CBTN Datasets
Almost all of the DNA of the human genome is located on 23 pairs of chromosomes, each a long coil of a single tightly-wound DNA strand. When a…