Chordoma Foundation Biobank
Background The Chordoma Foundation (CF) biospecimens, clinical and genomic data via the expertise and tools created by the Center for Data Driven Discovery (D3b) at the Children’s Hospital…
Oligo Nation
Oligodendroglioma Oligodendroglioma (Oligo) is a primary malignant brain cancer that develops from Oligodendrocytes. Oligodendroglioma is one of the more common types of glioma (which also includes Glioblastoma Multiforme…
Pario Group – Congenital Birth Defect Biobanking for Genetic Research
Pario Group is a genetic research effort to store samples from cohorts of congenital birth defects in children in order to improve doctors’ abilities to assess the long-term…
Cole-Reagins Registry for Sinonasal Cancer (CORSICA)
About CORSICA Funded by the Cole-Reagins Family Foundation after the death of a family member from sinus cancer, the Cole-Reagins Registry for Sinonasal Cancer (CORSICA) is a Stanford…
The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system
Abstract PURPOSE: Clinicians and researchers must contextualize a patient’s genetic variants against population-based references with detailed phenotyping. We sought to establish globally scalable technology, policy, and procedures for…
Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models
Abstract Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. PARP-1 is…
Pediatric spinal cord biopsy: A case series from a high-volume referral center
Abstract Pediatric patients presenting with intramedullary spinal cord lesions often require specific diagnoses to guide their treatment plans. Though results from magnetic resonance imaging and lumbar puncture may…
Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma
Abstract Neuroblastoma is a cancer of the developing sympathetic nervous system. It is diagnosed in 600-700 children per year in the United States and accounts for 12% of…
A pilot precision medicine trial for children with diffuse intrinsic pontine glioma—PNOC 003: A report from the Pacific Pediatric Neuro‐Oncology Consortium
Abstract This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing (RNAseq) of paired normal and tumor tissues could be incorporated into a personalized treatment plan…
Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers
Abstract Gene fusions are one of the most common genomic alterations in pediatric cancer. Many fusions encode oncogenic drivers and play important roles in cancer diagnosis, risk stratification,…