Adding Value to Liquid Biopsy for Brain Tumors: The Role of Imaging
Clinical management in neuro-oncology has shifted to an integrated method that combines molecular profiles with histopathological and imaging data. Liquid biopsy is a non-invasive method that captures the…
Radio-pathomic Approaches in Pediatric Neuro-Oncology; Opportunities and Challenges
With medical software platforms moving to cloud environments with scalable storage and computing, the translation of predictive artificial intelligence (AI) models to aid in clinical decision-making and facilitate…
Statistical Plots in Oncologic Imaging, A Primer for Neuroradiologists
The simplest approach to convey the results of scientific analysis, which can include complex comparisons, is typically through the use of visual items, including figures and plots. These…
Radiomics for Characterization of the Glioma Immune Microenvironment
Increasing evidence suggests that besides mutational and molecular alterations, the immune component of the tumor microenvironment also substantially impacts tumor behavior and complicates treatment response, particularly to immunotherapies….
Current State of Pediatric Neuro-oncology Imaging, Challenges and Future Directions
Imaging plays a central role in neuro-oncology including primary diagnosis, treatment planning, and surveillance of tumors. The emergence of quantitative imaging and radiomics provided an uprecedented opportunity to…
Unsupervised Machine Learning Using K-means Identifies Radiomic Subgroups of Pediatric Low-grade Gliomas that Correlate with Key Molecular Markers
Despite advancements in molecular and histopathologic characterization of pediatric low-grade gliomas (pLGGs), there remains significant phenotypic heterogeneity among tumors with similar categorizations. We hypothesized that an unsupervised machine…
Automated Tumor Segmentation and Brain Tissue Extraction from Multiparametric MRI of Pediatric Brain Tumors: A Multi-institutional Study
Brain tumors are the most common solid tumors and the leading cause of cancer-related death among all childhood cancers. Tumor segmentation is essential in surgical and treatment planning,…
Radiomics and Radiogenomics in Pediatric Neuro-oncology: A Review
The current era of advanced computing has allowed for the development and implementation of the field of radiomics. In pediatric neuro-oncology, radiomics has been applied in determination of…
Recurrent MSC(E116K) mutations in ALK-negative anaplastic large cell lymphoma
Abstract Anaplastic large cell lymphomas (ALCLs) represent a relatively common group of T-cell non-Hodgkin lymphomas (T-NHLs) that are unified by similar pathologic features but demonstrate marked genetic heterogeneity….
Reduction of ventriculostomy-associated CSF infection with antibiotic-impregnated catheters in pediatric patients: a single-institution study
Abstract OBJECTIVE External ventricular drains (EVDs) are commonly used in the neurosurgical population. However, very few pediatric neurosurgery studies are available regarding EVD-associated infection rates with antibiotic-impregnated EVD…