Lack of Sphenoid Pneumatization Does Not Affect Endoscopic Endonasal Pediatric Skull Base Surgery Outcomes
Abstract OBJECTIVES/HYPOTHESIS: Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing…
Phase II Study of Sorafenib in Children with Recurrent or Progressive Low-grade Astrocytomas
Abstract BACKGROUND: Activation of the RAS-RAF-MEK-ERK signaling pathway is thought to be the key driver of pediatric low-grade astrocytoma (PLGA) growth. Sorafenib is a multikinase inhibitor targeting BRAF,…
Intraoperative Intracranial Pressure Monitoring in the Pediatric Craniosynostosis Population
Objective Evaluation of increased intracranial pressure (ICP) in the pediatric craniosynostosis population based solely on ophthalmological, clinical, and radiographic data is subjective, insensitive, and inconsistent. The aim of…
MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric Leuke-mia
Abstract The outcome for pediatric acute lymphoblastic leukemia (ALL) patients who relapse is dismal. A hallmark of relapsed disease is acquired resistance to multiple chemotherapeutic agents, particularly glucocorticoids….
Pediatric low-grade gliomas: next biologically driven steps
Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neuro-oncology due to comorbidities associated with these tumors and/or…
A 6-Year-Old With Leg Cramps
A 6-year-old girl presented with a history of leg pain and cramping that progressively worsened over a 2- to 3-week period of time. Her examination was notable for…
MYB-QKI Drives Childhood Brain Tumors Via Tripartite Mechanism
Pediatric brain tumors are the leading cause of disease related death in children with pediatric low-grade gliomas (PLGGs) as the most commonly diagnosed sub-type. While surgery remains the…
Leaving tissue associated with infrequent intracranial EEG seizure onsets is compatible with post-operative seizure freedom
Abstract Identify seizure onset electrodes that need to be resected for seizure freedom in children undergoing intracranial electroencephalography recording for treatment of medically refractory epilepsy. All children undergoing…
Intratumoral genetic and functional heterogeneity in pediatric glioblastoma
Abstract Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole genome sequencing with…
Successful Microsurgical Extraction of a Migrated Coil in a Pediatric Patient After Failed Endovascular Closure of a Blalock-taussig Shunt. Case Report
Coil migration is a rare but potentially serious complication of endovascular procedures. Occasionally coils can be retrieved via endovascular techniques. The authors describe the microsurgical management of a…